Modified Poly(lactic‐ co ‐glycolic Acid) Nanoparticles for Enhanced Cellular Uptake and Gene Editing in the Lung | Zendy

Fields Rachel J. | Zendy; Quijano Elias | Zendy; McNeer Nicole Ali | Zendy; Caputo Christina | Zendy; Bahal Raman | Zendy; Anandalingam Kavi | Zendy; Egan Marie E. | Zendy; Glazer Peter M. | Zendy; Saltzman W. Mark | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Modified Poly(lactic‐ co ‐glycolic Acid) Nanoparticles for Enhanced Cellular Uptake and Gene Editing in the Lung

Author(s) -

Fields Rachel J.,

Quijano Elias,

McNeer Nicole Ali,

Caputo Christina,

Bahal Raman,

Anandalingam Kavi,

Egan Marie E.,

Glazer Peter M.,

Saltzman W. Mark

Publication year - 2015

Publication title -

advanced healthcare materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.288

H-Index - 90

eISSN - 2192-2659

pISSN - 2192-2640

DOI - 10.1002/adhm.201400355

Subject(s) - plga , glycolic acid , lactic acid , nanoparticle , gene delivery , chemistry , nanotechnology , materials science , biophysics , gene , biochemistry , genetic enhancement , biology , bacteria , genetics

Surface‐modified poly(lactic‐ co ‐glycolic acid) (PLGA)/poly(β‐aminoester)(PBAE)nanoparticles (NPs) have shown great promise in gene delivery. In this work, the pulmonary cellular uptake of these NPs is evaluated and surface‐modified PLGA/PBAE NPs are shown to achieve higher cellular association and gene editing than traditional NPs composed of PLGA or PLGA/PBAE blends alone.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research