Premium
Modified Poly(lactic‐ co ‐glycolic Acid) Nanoparticles for Enhanced Cellular Uptake and Gene Editing in the Lung
Author(s) -
Fields Rachel J.,
Quijano Elias,
McNeer Nicole Ali,
Caputo Christina,
Bahal Raman,
Anandalingam Kavi,
Egan Marie E.,
Glazer Peter M.,
Saltzman W. Mark
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400355
Subject(s) - plga , glycolic acid , lactic acid , nanoparticle , gene delivery , chemistry , nanotechnology , materials science , biophysics , gene , biochemistry , genetic enhancement , biology , bacteria , genetics
Surface‐modified poly(lactic‐ co ‐glycolic acid) (PLGA)/poly(β‐aminoester)(PBAE)nanoparticles (NPs) have shown great promise in gene delivery. In this work, the pulmonary cellular uptake of these NPs is evaluated and surface‐modified PLGA/PBAE NPs are shown to achieve higher cellular association and gene editing than traditional NPs composed of PLGA or PLGA/PBAE blends alone.