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Biocompatible Reactive Oxygen Species (ROS)‐Responsive Nanoparticles as Superior Drug Delivery Vehicles
Author(s) -
Zhang Dinglin,
Wei Yanling,
Chen Kai,
Zhang Xiangjun,
Xu Xiaoqiu,
Shi Qing,
Han Songling,
Chen Xin,
Gong Hao,
Li Xiaohui,
Zhang Jianxiang
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400299
Subject(s) - nanocarriers , reactive oxygen species , biocompatible material , drug delivery , nanotechnology , biocompatibility , computer science , materials science , chemistry , biomedical engineering , medicine , biochemistry , metallurgy
A novel reactive oxygen species (ROS)‐responsive nanoplatform can be successfully manufactured from a ROS‐triggerable β‐cyclodextrin material. Extensive in vitro and in vivo studies validate that this nanoscaled system may serve as a new drug delivery vehicle with well‐defined ROS‐sensitivity and superior biocompatibility. This nanocarrier can be used for ROS‐triggered transport of diverse therapeutics and imaging agents.