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Directing Stem Cell Differentiation by Changing the Molecular Mobility of Supramolecular Surfaces
Author(s) -
Seo JiHun,
Kakinoki Sachiro,
Yamaoka Tetsuji,
Yui Nobuhiko
Publication year - 2015
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400173
Subject(s) - stem cell , materials science , cytoskeleton , copolymer , nanotechnology , polymer , cellular differentiation , biophysics , cell , microbiology and biotechnology , chemistry , biology , biochemistry , composite material , gene
Polymer surfaces with a wide range of hydrated surface mobility are developed by a simple deposition method with supramolecular block copolymers. The morphologies of adhering stem cells are greatly dependent on the surface mobility of polymers, and this induces significant changes in the cytoskeletal signaling pathway to direct the downstream stem cell differentiation.