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The Construction of Tissue‐Engineered Blood Vessels Crosslinked with Adenosine‐Loaded Chitosan/β‐Cyclodextrin Nanoparticles using a Layer‐by‐Layer Assembly Method
Author(s) -
Chen Wen,
Zeng Wen,
Wu Yangxiao,
Wen Can,
Li Li,
Liu Ge,
Shen Lei,
Yang Mingcan,
Tan Ju,
Zhu Chuhong
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400167
Subject(s) - homing (biology) , adenosine , chitosan , nanoparticle , cyclodextrin , nanotechnology , layer (electronics) , computer science , biomedical engineering , materials science , chemistry , engineering , biochemistry , physics , geophysics
A tissue‐engineered blood vessel (TEBV) modified with CS/β‐CD nanoparticles is constructed, effectively controling the release of adenosine, and this type of TEBV can keep open for over 6 months. This study also demonstrates for the first time that adenosine promotes endothelial progenitor cell (EPC) mobilization and homing via energy conversion, achieving rapid endothelialization of TEBV.