Premium
The Aspect Ratio of Nanoparticle Assemblies and the Spatial Arrangement of Ligands can be Optimized to Enhance the Targeting of Cancer Cells
Author(s) -
Wen Amy M.,
Steinmetz Nicole F.
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400141
Subject(s) - nanoparticle , materials science , nanotechnology , cancer cell , aspect ratio (aeronautics) , cell , cancer , biophysics , chemistry , biochemistry , biology , optoelectronics , genetics
Two are better than one: A novel, bottom‐up approach using virus‐based nanoparticles is developed for the synthesis of dimers and assemblies up to an aspect ratio of 8. Cell uptake is shown to depend on nanoparticle shape and is enhanced for dimers compared with single particles. Symmetrical rather than topo‐selective presentation of RGD peptides further enhances cancer cell targeting.