Premium
A Symmetrical Fluorous Dendron‐Cyanine Dye‐Conjugated Bimodal Nanoprobe for Quantitative 19 F MRI and NIR Fluorescence Bioimaging
Author(s) -
Wang Zhe,
Yue Xuyi,
Wang Yu,
Qian Chunqi,
Huang Peng,
Lizak Marty,
Niu Gang,
Wang Fu,
Rong Pengfei,
Kiesewetter Dale O.,
Ma Ying,
Chen Xiaoyuan
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400088
Subject(s) - nanoprobe , cyanine , dendrimer , fluorescence , conjugated system , materials science , analytical chemistry (journal) , nanotechnology , nuclear magnetic resonance , photochemistry , chemistry , polymer chemistry , optics , nanoparticle , organic chemistry , polymer , physics , composite material
19 F MRI and optical imaging are two powerful noninvasive molecular imaging modalities in biomedical applications. 19 F MRI has great potential for high resolution in vivo imaging, while fluorescent probes enable ultracontrast cellular/tissue imaging with high accuracy and sensitivity. A bimodal nanoprobe is developed, integrating the merits of 19 F MRI and fluorescence imaging into a single synthetic molecule, which is further engineered into nanoprobe, by addressing shortcomings of conventional contrast agents to explore the quantitative 19 F MRI and fluorescence imaging and cell tracking. Results show that this bimodal imaging nanoprobe presents high correlation of 19 F MR signal and NIR fluorescence intensity in vitro and in vivo. Additionally, this nanoprobe enables quantitative 19 F MR analysis, confirmed by a complementary fluorescence analysis. This unique feature can hardly be obtained by traditional 19 F MRI contrast agents. It is envisioned that this nanoprobe can hold great potential for quantitative and sensitive multi‐modal molecular imaging.