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Assessing Cellular Response to Functionalized α‐Helical Peptide Hydrogels
Author(s) -
Mehrban Nazia,
Abelardo Edgardo,
Wasmuth Alexandra,
Hudson Kieran L.,
Mullen Leanne M.,
Thomson Andrew R.,
Birchall Martin A.,
Woolfson Derek N.
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400065
Subject(s) - self healing hydrogels , peptide , materials science , self assembling peptide , biophysics , nanotechnology , chemistry , biochemistry , polymer chemistry , biology
α‐Helical peptide hydrogels are decorated with a cell‐binding peptide motif (RGDS), which is shown to promote adhesion, proliferation, and differentiation of PC12 cells. Gel structure and integrity are maintained after functionalization. This opens possibilities for the bottom‐up design and engineering of complex functional scaffolds for 2D and 3D cell cultures.