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Nanoengineered Particles for Enhanced Intra‐Articular Retention and Delivery of Proteins
Author(s) -
Singh Ankur,
Agarwal Rachit,
DiazRuiz Carlos A.,
Willett Nick J.,
Wang Peiyi,
Lee L. Andrew,
Wang Qian,
Guldberg Robert E.,
García Andrés J.
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400051
Subject(s) - osteoarthritis , materials science , articular cartilage , nanoparticle , biomedical engineering , particle size , nanotechnology , chemistry , medicine , pathology , alternative medicine
Localized intra‐articular delivery of anti‐inflammatory proteins can reduce inflammation in osteoarthritis but poses a challenge because of raid clearance within few hours of injection. A new class of polymer is developed that forms self‐assembled nanoparticles ranging from 300 to 900 nm and demonstrates particle size dependent prolonged retention in intra‐articular joint spaces compared to bolus protein over a period of 14 d.
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