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Carbon Nanotube Composites as Multifunctional Substrates for In Situ Actuation of Differentiation of Human Neural Stem Cells
Author(s) -
Landers John,
Turner Jeffrey T.,
Heden Greg,
Carlson Aaron L.,
Bennett Neal K.,
Moghe Prabhas V.,
Neimark Alexander V.
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400042
Subject(s) - materials science , carbon nanotube , extracellular matrix , substrate (aquarium) , nanotechnology , neural stem cell , in situ , stem cell , microbiology and biotechnology , chemistry , biology , ecology , organic chemistry
For the first time , single‐walled carbon nanotube–polymer composites are shown to enhance human neural stem cell (NSC) differentiation with electrical stimulation. The substrates are electrically conductive, mechanically robust, and highly biocompatible with human NSC cultures. The substrate's fibrous topography mimicking the extracellular matrix enhances neuronal lineage expression and electro‐conductivity provides means for controlled stimulation of neuronal maturation.