z-logo
Premium
Enhanced Intracellular siRNA Delivery using Bioreducible Lipid‐Like Nanoparticles
Author(s) -
Wang Ming,
Alberti Kyle,
Varone Antonio,
Pouli Dimitria,
Georgakoudi Irene,
Xu Qiaobing
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400039
Subject(s) - intracellular , gene knockdown , small interfering rna , nanoparticle , rna interference , biophysics , nanotechnology , degradation (telecommunications) , microbiology and biotechnology , chemistry , materials science , transfection , gene , biochemistry , biology , rna , computer science , telecommunications
A new library of lipid‐like nanoparticles (lipidoids) comprising disulfide bond is developed for siRNA delivery. Bioreducible lipidoids deliver siRNA with greater efficiency than nonbioreducible lipidoids with similar chemical structures. A siRNA release investigation, as well as an intracellular siRNA trafficking study, reveals that the degradation of bioreducible lipidoid in a strongly reductive intracellular environment boosts siRNA release and enhances siRNA gene knockdown efficiency.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here