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Peptide‐Directed Spatial Organization of Biomolecules in Dynamic Gradient Scaffolds
Author(s) -
Chow Lesley W.,
Armgarth Astrid,
StPierre JeanPhilippe,
Bertazzo Sergio,
Gentilini Cristina,
Aurisicchio Claudia,
McCullen Seth D.,
Steele Joseph A. M.,
Stevens Molly M.
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400032
Subject(s) - biomolecule , nanotechnology , peptide , computer science , scaffold , chemistry , computational biology , biophysics , materials science , biochemistry , biology , database
Specific binding peptides are used to spatially organize biomolecule gradients within an electrospun fiber scaffold. Different biomolecule‐binding peptide–polymer conjugates are sequentially co‐electrospun with a fiber‐forming host polymer to generate opposing gradients of peptide functionalization. The binding peptides specifically and non‐covalently guide the spatial arrangement of biomolecules into dynamic gradients within the scaffold, mimicking biological gradients found in native tissues.