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Polymeric‐Gold Nanohybrids for Combined Imaging and Cancer Therapy
Author(s) -
Topete Antonio,
AlatorreMeda Manuel,
VillarAlvarez Eva M.,
CarregalRomero Susana,
Barbosa Silvia,
Parak Wolfgang J.,
Taboada Pablo,
Mosquera Víctor
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400023
Subject(s) - photothermal therapy , materials science , plga , hela , nanotechnology , nanoparticle , cancer cell , doxorubicin , surface modification , photothermal effect , superparamagnetism , biophysics , colloidal gold , internalization , in vitro , cancer , chemistry , cell , biochemistry , medicine , magnetization , biology , quantum mechanics , magnetic field , physics , surgery , chemotherapy
Here, the use of folic acid (FA)‐functionalized, doxorubicin (DOXO)/superparamagnetic iron oxide nanoparticles (SPION)‐loaded poly(lactic‐ co ‐glycolic acid) (PLGA)‐Au porous shell nanoparticles (NPs) as potential nanoplatforms is reported for targeted multimodal chemo‐ and photothermal therapy combined with optical and magnetic resonance imaging in cancer. These polymeric‐gold nanohybrids (PGNH) are produced by a seeded‐growth method using chitosan as an electrostatic “glue” to attach Au seeds to DOXO/SPION‐PLGA NPs. In order to determine their potential as theranostic nanoplatforms, their physicochemical properties, cellular uptake, and photothermal and chemotherapeutic efficiencies are tested in vitro using a human cervical cancer (HeLa) cell line. The present NPs show a near‐infrared (NIR)‐light‐triggered release of cargo molecules under illumination and a great capacity to induce localized cell death in a well‐focused region. The functionalization of the PGNH NPs with the targeting ligand FA improves their internalization efficiency and specificity. Furthermore, the possibility to guide the PGNH NPs to cancer cells by an external magnetic field is also proven in vitro, which additionally increases the cellular uptake and therapeutic efficiency.