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A FRET‐Based Dual‐Targeting Theranostic Chimeric Peptide for Tumor Therapy and Real‐time Apoptosis Imaging
Author(s) -
Han Kai,
Liu Yun,
Yin WeiNa,
Wang ShiBo,
Xu Qi,
Zhuo RenXi,
Zhang XianZheng
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400020
Subject(s) - apoptosis , förster resonance energy transfer , peptide , dual (grammatical number) , computer science , fluorescence , nanotechnology , computational biology , tumor cells , chemistry , cancer research , biology , materials science , biochemistry , physics , art , optics , literature
A FRET‐based chimeric peptide is reported to mediate specific tumor cell uptaking and apoptosis. Importantly, this chimeric peptide is fluorescence quenched (OFF). Once the apoptosis is initiated and propagated, green fluorescence is lighted up rapidly (ON), achieving simultaneous tumor therapy and real‐time apoptosis monitoring.