z-logo
Premium
Nucleotides as Nontoxic Endogenous Endosomolytic Agents in Drug Delivery
Author(s) -
Cho Hana,
Cho YongYeon,
Bae You Han,
Kang Han Chang
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400008
Subject(s) - nucleotide , guanosine , endogeny , chemistry , adenosine triphosphate , biochemistry , nucleic acid , nanocarriers , drug delivery , computational biology , biology , gene , organic chemistry
Nontoxic endogenous nucleotides such as adenosine triphosphate and guanosine triphosphate have secondary phosphate groups, causing proton‐buffering capacity and/or hemolytic activity in endolysosomal pH ranges. Nucleotides co‐delivered in single polymeric pDNA nanocarrier induce highly enhanced transfection efficiency with negligible cytotoxicity due to their endosomolytic functions.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here