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Nucleotides as Nontoxic Endogenous Endosomolytic Agents in Drug Delivery
Author(s) -
Cho Hana,
Cho YongYeon,
Bae You Han,
Kang Han Chang
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201400008
Subject(s) - nucleotide , guanosine , endogeny , chemistry , adenosine triphosphate , biochemistry , nucleic acid , nanocarriers , drug delivery , computational biology , biology , gene , organic chemistry
Nontoxic endogenous nucleotides such as adenosine triphosphate and guanosine triphosphate have secondary phosphate groups, causing proton‐buffering capacity and/or hemolytic activity in endolysosomal pH ranges. Nucleotides co‐delivered in single polymeric pDNA nanocarrier induce highly enhanced transfection efficiency with negligible cytotoxicity due to their endosomolytic functions.