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Graphene: Insight into the Cellular Internalization and Cytotoxicity of Graphene Quantum Dots (Adv. Healthcare Mater. 12/2013)
Author(s) -
Wu Congyu,
Wang Chong,
Han Ting,
Zhou Xuejiao,
Guo Shouwu,
Zhang Jingyan
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201370062
Subject(s) - graphene , endocytosis , cytotoxicity , internalization , quantum dot , nanotechnology , caveolae , cytoplasm , materials science , nanomedicine , endoplasmic reticulum , nanochemistry , oxide , biophysics , nanoparticle , chemistry , microbiology and biotechnology , cell , biology , biochemistry , in vitro , metallurgy
On page 1613 Shouwu Guo and co‐workers present how graphene quantum dots (GQDs) with unique morphology and ultrasmall lateral sizes are internalized primarily via caveolae‐mediated endocytosis, and tend to accumulate in the endoplasmic reticulum and nucleus. The GQDs also exhibit lower cytotoxicity than that of the micrometer‐sized graphene oxide, which prefers to stay in the cytoplasm. The subcellular distribution and low cytotoxicity of GQDs hold great promise in biomedical applications.