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Drug Solubility: Mesoporous Calcium Carbonate as a Phase Stabilizer of Amorphous Celecoxib – An Approach to Increase the Bioavailability of Poorly Soluble Pharmaceutical Substances (Adv. Healthcare Mater. 11/2013)
Author(s) -
Forsgren Johan,
Andersson Mattias,
Nilsson Peter,
Mihranyan Albert
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201370054
Subject(s) - vaterite , bioavailability , amorphous calcium carbonate , solubility , stabilizer (aeronautics) , amorphous solid , materials science , drug , chemical engineering , calcium carbonate , celecoxib , phase (matter) , aqueous solution , chemistry , mesoporous material , nuclear chemistry , pharmacology , organic chemistry , biochemistry , medicine , catalysis , aragonite , mechanical engineering , engineering
On page 1469 , Johan Forsgren, Albert Mihranyan, and co‐workers show how vaterite is used as a phase stabilizer of amorphous celecoxib, resulting in the increase of the apparent aqueous solubility of the substance. The presented results show promise for the use of vaterite to achieve enhanced bioavailability in new formulations of Type II BCS drugs.