Cell Migration: Tunable Substrates Unveil Chemical Complementation of a Genetic Cell Migration Defect (Adv. Healthcare Mater. 8/2013) | Zendy

Hellmann Janina Kristin | Zendy; Perschmann Nadine | Zendy; Spatz Joachim P. | Zendy; Frischknecht Friedrich | Zendy

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Cell Migration: Tunable Substrates Unveil Chemical Complementation of a Genetic Cell Migration Defect (Adv. Healthcare Mater. 8/2013)

Author(s) -

Hellmann Janina Kristin,

Perschmann Nadine,

Spatz Joachim P.,

Frischknecht Friedrich

Publication year - 2013

Publication title -

advanced healthcare materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.288

H-Index - 90

eISSN - 2192-2659

pISSN - 2192-2640

DOI - 10.1002/adhm.201370044

Subject(s) - motility , cell migration , complementation , materials science , microbiology and biotechnology , cell , substrate (aquarium) , cell adhesion , adhesion , actin cytoskeleton , actin , biophysics , cytoskeleton , chemistry , phenotype , biology , biochemistry , composite material , ecology , gene

Sporozoite motility is essential for malaria transmission and constitutes the first target for intervention within the human body. On page 1162 J. P. Spatz, F. Frischknecht, and co‐workers use a set of tunable substrates with changed ligand spacing and elasticity to show that a small chemical compound that stabilizes the actin cytoskeleton can compensate the motility defects of parasites that lack a surface protein important for substrate adhesion.

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