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Cell Migration: Tunable Substrates Unveil Chemical Complementation of a Genetic Cell Migration Defect (Adv. Healthcare Mater. 8/2013)
Author(s) -
Hellmann Janina Kristin,
Perschmann Nadine,
Spatz Joachim P.,
Frischknecht Friedrich
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201370044
Subject(s) - motility , cell migration , complementation , materials science , microbiology and biotechnology , cell , substrate (aquarium) , cell adhesion , adhesion , actin cytoskeleton , actin , biophysics , cytoskeleton , chemistry , phenotype , biology , biochemistry , composite material , ecology , gene
Sporozoite motility is essential for malaria transmission and constitutes the first target for intervention within the human body. On page 1162 J. P. Spatz, F. Frischknecht, and co‐workers use a set of tunable substrates with changed ligand spacing and elasticity to show that a small chemical compound that stabilizes the actin cytoskeleton can compensate the motility defects of parasites that lack a surface protein important for substrate adhesion.