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Drug Delivery: Antibody‐Functionalized Porous Silicon Nanoparticles for Vectorization of Hydrophobic Drugs (Adv. Healthcare Mater. 5/2013)
Author(s) -
Secret Emilie,
Smith Kevin,
Dubljevic Valentina,
Moore Eli,
Macardle Peter,
Delalat Bahman,
Rogers MaryLouise,
Johns Terrance G.,
Durand JeanOlivier,
Cunin Frédérique,
Voelcker Nicolas H.
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201370025
Subject(s) - camptothecin , porous silicon , drug delivery , materials science , nanoparticle , drug , cancer cell , nanotechnology , in vitro , cancer , targeted drug delivery , silicon , chemistry , pharmacology , medicine , organic chemistry , biochemistry , metallurgy
Biodegradable porous silicon nanoparticles (pSiNP) functionalized with cancer cell targeting antibodies and loaded with the hydrophobic anti‐cancer drug camptothecin are developed by Nicolas H. Voelcker, Frédérique Cunin, and co‐workers on page 718 . High targeting and killing efficiency is demonstrated in vitro on three types of cancer cells: neuroblastoma, glioblastoma and lymphoma cells.