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Drug Delivery: Platinum (IV) Pro‐Drug Conjugated NaYF 4 :Yb 3+ /Er 3+ Nanoparticles for Targeted Drug Delivery and Up‐Conversion Cell Imaging (Adv. Healthcare Mater. 4/2013)
Author(s) -
Dai Yunlu,
Kang Xiaojiao,
Yang Dongmei,
Li Xuejiao,
Zhang Xiao,
Li Chunxia,
Hou Zhiyao,
Cheng Ziyong,
Ma Ping'an,
Lin Jun
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201370019
Subject(s) - platinum , drug delivery , conjugated system , materials science , photon upconversion , nanoparticle , nanotechnology , drug , platinum nanoparticles , nuclear chemistry , chemistry , luminescence , catalysis , medicine , organic chemistry , pharmacology , polymer , optoelectronics , composite material
A folic acid targeted anticancer drug delivery system based on Pt (IV) complexes pro‐drug conjugated upconversion NaYF 4 :Yb 3+ /Er 3+ nanoparticles is developed. As reported by Jun Lin, Ping'an Ma, and co‐workers on page 562 , the platinum (IV) complexes as pro‐drugs can exhibit anti‐cancer activities when the platinum (IV) complexes are reduced to platinum (II) in the intracellular environment. The nanoparticles show bright upconversion fluorescence under 980 nm laser excitation; thus, the as‐prepared nanoparticles can be used as a luminescent probe for up‐conversion cell imaging.