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Drug Delivery: Efficient, pH‐Triggered Drug Delivery Using a pH‐Responsive DNA‐Conjugated Gold Nanoparticle (Adv. Healthcare Mater. 2/2013)
Author(s) -
Song Lei,
Ho Vincent H.B.,
Chen Chun,
Yang Zhongqiang,
Liu Dongsheng,
Chen Rongjun,
Zhou Dejian
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201370008
Subject(s) - endosome , drug delivery , conjugate , colloidal gold , drug , conjugated system , intracellular , dna , nanoparticle , cytotoxicity , chemistry , cancer cell , nanotechnology , biophysics , biochemistry , materials science , pharmacology , cancer , polymer , in vitro , biology , organic chemistry , mathematical analysis , genetics , mathematics
A novel pH‐responsive DNA–gold nanoparticle conjugate that has high drug load, resists non‐specific serum protein adsorption and has high endocytotic cellular uptake is developed by Dejian Zhou, Rongjun Chen, and co‐workers on page 275 . Upon acidification in intracellular endosomes/lysosomes, the formation of intramolecular i‐motif by the pH‐responsive DNA leads to efficient, pH‐triggered release of the anticancer drugs inside cancer cells, and hence high cytotoxicity.