Premium
Stem Cells: Phenotypic and Transcriptional Modulation of Human Pluripotent Stem Cells Induced by Nano/Microfabrication Materials (Adv. Healthcare Mater. 2/2013)
Author(s) -
Kamei Kenichiro,
Hirai Yoshikazu,
Yoshioka Momoko,
Makino Yoshihide,
Yuan Qinghua,
Nakajima Minako,
Chen Yong,
Tabata Osamu
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201370007
Subject(s) - induced pluripotent stem cell , microfabrication , polydimethylsiloxane , materials science , nanotechnology , biocompatibility , human induced pluripotent stem cells , microbiology and biotechnology , stem cell , embryonic stem cell , biomedical engineering , biology , medicine , fabrication , biochemistry , pathology , alternative medicine , gene , metallurgy
Polymer‐based microfabrication materials such as polydimethylsiloxane (PDMS) and photoresists (PRs) permit the creation of nano/microstructured substrates that enable the direct control of the cellular functions and phenotypes of human pluripotent stem cells (hPSCs), but their biocompatibility and effects on hPSCs are poorly understood. On page 287 , Osamu Tabata, Kenichiro Kamei, and co‐workers reveal that the tested materials preferentially direct hPSCs towards differentiation. The image depicts how PRs (yellow), PDMS (light blue) and glass (white) influence the capability of hPSC differentiation into various tissues, such as muscle, heart and neurons.