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Hyperthermia‐Induced Drug Delivery from Thermosensitive Liposomes Encapsulated in an Injectable Hydrogel for Local Chemotherapy
Author(s) -
LópezNoriega Adolfo,
Hastings Conn L.,
Ozbakir Burcin,
O'Donnell Kathleen E.,
O'Brien Fergal J.,
Storm Gert,
Hennink Wim E.,
Duffy Garry P.,
RuizHernández Eduardo
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201300649
Subject(s) - drug delivery , liposome , drug , doxorubicin , chitosan , anticancer drug , nanotechnology , computer science , materials science , chemotherapy , pharmacology , chemistry , medicine , surgery , biochemistry
A novel drug delivery system , enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin‐loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on‐demand drug delivery with in situ gelation results in a promising candidate for local chemotherapy.