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Macromolecular Prodrugs of Ribavirin: Concerted Efforts of the Carrier and the Drug
Author(s) -
Smith Anton A. A.,
Wohl Benjamin M.,
Kryger Mille B. L.,
Hedemann Natasha,
GuerreroSanchez Carlos,
Postma Almar,
Zelikin Alexander N.
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201300637
Subject(s) - ribavirin , prodrug , drug , broad spectrum , computer science , macromolecule , nanotechnology , combinatorial chemistry , chemistry , pharmacology , medicine , materials science , virology , virus , biochemistry , hepatitis c virus
Polymers in tune . Automated parallel polymer synthesis is developed to obtain libraries of macromolecular prodrugs of ribavirin, a broad‐spectrum antiviral agent. As many as 10 identified lead polymer conjugates exhibit therapeutic efficacy matching that of the pristine drug and at the same time suppressed the origin of the main side effect of ribavirin.