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Biomimetic Interfaces Reveal Activation Dynamics of C‐Reactive Protein in Local Microenvironments
Author(s) -
Goda Tatsuro,
Kjall Peter,
Ishihara Kazuhiko,
RichterDahlfors Agneta,
Miyahara Yuji
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201300625
Subject(s) - phosphorylcholine , inflammation , microbiology and biotechnology , complement system , immune system , innate immune system , biophysics , receptor , cell , cell membrane , biology , chemistry , immunology , biochemistry
A cell‐membrane‐mimetic surface with an organic bioelectronic ion pump system creates an in vitro situation that replicates the pathogenic progression on a sensing platform to investigate the molecular dynamics of C‐reactive protein (CRP) to its receptor on cell membrane changes by local microenvironments in acute phase of inflammation and infection.