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High Aspect Ratio Elongated Microparticles for Enhanced Topical Drug Delivery in Human Volunteers
Author(s) -
Raphael Anthony P.,
Primiero Clare A.,
Lin Lynlee L.,
Smith Ross Flewell,
Dyer Philip,
Soyer H. Peter,
Prow Tarl W.
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201300517
Subject(s) - drug delivery , content delivery , nanotechnology , computer science , field (mathematics) , biomedical engineering , materials science , medicine , computer network , mathematics , pure mathematics
Delivery of therapeutics into skin is hindered by the epidermal barriers . To overcome these barriers for the treatment of skin diseases, a cutaneous delivery method capable of field treatment using silica‐elongated microparticles is developed. The microparticles are massaged into the skin using a 3D‐printed microtextured applicator resulting in significant field‐directed drug delivery enhancement.