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Whole Blood Cells Loaded with Messenger RNA as an Anti‐Tumor Vaccine
Author(s) -
Phua Kyle K. L.,
Boczkowski David,
Dannull Jens,
Pruitt Scott,
Leong Kam W.,
Nair Smita K.
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201300512
Subject(s) - messenger rna , rna , ex vivo , immunization , antigen , in vivo , whole blood , immunology , medicine , virology , biology , gene , genetics
The use of a cell‐based vaccine composed of autologous whole blood cells loaded with mRNA is described. Mice immunized with whole blood cells loaded with mRNA encoding antigen develop anti‐tumor immunity comparable to DC‐RNA immunization. This approach offers a simple and affordable alternative to RNA‐based cellular therapy by circumventing complex, laborious and expensive ex vivo manipulations required for DC‐based immunizations.