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High‐Density Polymer Microarrays: Identifying Synthetic Polymers that Control Human Embryonic Stem Cell Growth
Author(s) -
Hansen Anne,
Mjoseng Heidi K.,
Zhang Rong,
Kalloudis Michail,
Koutsos Vasileios,
de Sousa Paul A.,
Bradley Mark
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201300489
Subject(s) - embryonic stem cell , polymer , computer science , nanotechnology , stem cell , fabrication , materials science , computational biology , biology , microbiology and biotechnology , gene , genetics , medicine , alternative medicine , pathology , composite material
The fabrication of high‐density polymer microarray is described, allowing the simultaneous and efficient evaluation of more than 7000 different polymers in a single‐cellular‐based screen. These high‐density polymer arrays are applied in the search for synthetic substrates for hESCs culture. Up‐scaling of the identified hit polymers enables long‐term cellular cultivation and promoted successful stem‐cell maintenance.