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A General Strategy for Dual‐Triggered Combined Tumor Therapy Based on Template Semi‐Graphitized Mesoporous Silica Nanoparticles
Author(s) -
Wang Yi,
Wang Kaiyuan,
Yan Xueying,
Huang Rongqin
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201300324
Subject(s) - photothermal therapy , mesoporous silica , materials science , nanoparticle , doxorubicin , nanotechnology , mesoporous material , mesoporous organosilica , dual (grammatical number) , pulmonary surfactant , chemistry , catalysis , organic chemistry , chemotherapy , medicine , biochemistry , art , surgery , literature
A general strategy is developed for dual‐triggered chemo‐photothermal tumor therapy based on template semi‐graphitized mesoporous silica nanoparticles (TsGMSN). The strategy endues classic MSN with new charming properties, while easily escaping from toxicity of the surfactant. The doxorubicin‐loaded system (TsGMSND) exhibits synergistic heat‐stimulative, pH‐responsive, and sustained release, and effective combined tumor therapy.