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Photoactive Electrospun Fibers for Inducing Cell Death
Author(s) -
Gabriel Doris,
CohenKarni Tzahi,
Huang David,
Chiang Homer H.,
Kohane Daniel S.
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201300318
Subject(s) - photosensitizer , phototoxicity , reactive oxygen species , macromolecule , programmed cell death , materials science , nanotechnology , computer science , chemistry , apoptosis , photochemistry , in vitro , biochemistry
A photoactive electrospun material producing reactive oxygen species (ROS) upon light irradiation is reported. The phototoxicity of the generated ROS is spatially restricted to the fiber–tissue interface by conjugation of the photosensitizer to a macromolecule. Photo‐triggered ROS is produced on demand and repeatedly. It induces death of mammalian cells growing on the material surface with high spatial resolution