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Autophagy‐Sensitized Cytotoxicity of Quantum Dots in PC12 Cells
Author(s) -
Li Xiaoming,
Chen Nan,
Su Yuanyuan,
He Yao,
Yin Min,
Wei Min,
Wang Lianhui,
Huang Wei,
Fan Chunhai,
Huang Qing
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201300294
Subject(s) - cadmium telluride photovoltaics , autophagy , cytotoxicity , cadmium , quantum dot , chemistry , nanotechnology , ion , cancer research , computer science , materials science , microbiology and biotechnology , biology , biochemistry , in vitro , apoptosis , organic chemistry
Both CdTe and CdTe/CdS/ZnS quantum dots induce similar levels of autophagy in PC12 and HEK293 cells, while the former exhibits higher toxicity. Low levels of cadmium ions are not sufficient to induce either autophagy or cytotoxicity by themselves. Interestingly, the combination of cadmium ions and CdTe/CdS/ZnS mimics the toxic effect of CdTe, suggesting that autophagy sensitizes cells to cadmium ions.