Premium
Graphene‒Regulated Cardiomyogenic Differentiation Process of Mesenchymal Stem Cells by Enhancing the Expression of Extracellular Matrix Proteins and Cell Signaling Molecules
Author(s) -
Park Jooyeon,
Park Subeom,
Ryu Seungmi,
Bhang Suk Ho,
Kim Jangho,
Yoon JeongKee,
Park Yoon Hwan,
Cho SungPyo,
Lee Seahyoung,
Hong Byung Hee,
Kim ByungSoo
Publication year - 2014
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201300177
Subject(s) - mesenchymal stem cell , microbiology and biotechnology , extracellular matrix , stem cell , cell signaling , cell culture , matrix (chemical analysis) , cell , chemistry , nanotechnology , biology , materials science , signal transduction , biochemistry , genetics , chromatography
The potential of graphene as a mesenchymal stem cell (MSC) culture substrate to promote cardiomyogenic differentiation is demonstrated. Graphene exhibits no sign of cytotoxicity for stem cell culture. MSCs are committed toward cardiomyogenic lineage by simply culturing them on graphene. This may be attributed, at least partially, to the regulation of expression levels of extracellular matrix and signaling molecules.