Immobilization of Actively Thromboresistant Assemblies on Sterile Blood‐Contacting Surfaces | Zendy

Qu Zheng | Zendy; Krishnamurthy Venkat | Zendy; Haller Carolyn A. | Zendy; Dorr Brent M. | Zendy; Marzec Ulla M. | Zendy; Hurst Sawan | Zendy; Hinds Monica T. | Zendy; Hanson Stephen R. | Zendy; Liu David R. | Zendy; Chaikof Elliot L. | Zendy

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Immobilization of Actively Thromboresistant Assemblies on Sterile Blood‐Contacting Surfaces

Author(s) -

Qu Zheng,

Krishnamurthy Venkat,

Haller Carolyn A.,

Dorr Brent M.,

Marzec Ulla M.,

Hurst Sawan,

Hinds Monica T.,

Hanson Stephen R.,

Liu David R.,

Chaikof Elliot L.

Publication year - 2014

Publication title -

advanced healthcare materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.288

H-Index - 90

eISSN - 2192-2659

pISSN - 2192-2640

DOI - 10.1002/adhm.201300110

Subject(s) - thrombomodulin , point of care , heparin , computer science , mutant , nanotechnology , biomedical engineering , chemistry , materials science , medicine , surgery , biochemistry , gene , platelet , pathology , immunology , thrombin

Rapid one‐step modification of thrombomodulin with alkylamine derivatives such as azide, biotin, and PEG is achieved using an evolved sortase (eSrtA) mutant. The feasibility of a point‐of‐care scheme is demonstrated herein to site‐specifically immobilize azido‐thrombomodulin on sterilized commercial ePTFE vascular grafts, which exhibit superior thromboresistance compared with commercial heparin‐coated grafts in a primate model of acute graft thrombosis.

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