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Engineering Polymeric Microparticles as Theranostic Carriers for Selective Delivery and Cancer Therapy
Author(s) -
Win Khin Yin,
Ye Enyi,
Teng Choon Peng,
Jiang Shan,
Han MingYong
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201300077
Subject(s) - drug delivery , nanotechnology , cancer therapy , cancer , cancer cell , nanoparticle , tumor cells , drug carrier , materials science , computer science , cancer research , medicine
Multifunctional polymeric nano‐ and microparticles are engineered as theranostic carriers and their selective size‐dependent cellular uptake is demonstrated. It is found that effective uptake and accumulation of nanoparticles occurs in both normal and cancer cells, whereas, that of microparticles occurs in cancer cells but not in normal cells, allowing cancer cells to be specifically targeted for local drug delivery.