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Combined Effect of Mussel‐Inspired Surface Modification and Topographical Cues on the Behavior of Skeletal Myoblasts
Author(s) -
Ku Sook Hee,
Park Chan Beum
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201300067
Subject(s) - nanofiber , myogenesis , multinucleate , myocyte , surface modification , mussel , materials science , skeletal muscle , microbiology and biotechnology , nanotechnology , biophysics , chemistry , anatomy , biology , ecology
The combined effect of mussel‐inspired polydopamine (PDA) surface functionalization and topographical cues on the behavior of skeletal myoblasts is described. On PDA‐modified nanofibers, myogenic protein expression and the fusion of myoblasts are increased significantly compared with those on unmodified nanofibers. The multinucleate myotubes on the aligned nanofibers are oriented in a direction parallel to the nanofibers.