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Antibody‐Functionalized Magnetic Polymersomes: In vivo Targeting and Imaging of Bone Metastases using High Resolution MRI
Author(s) -
Pourtau Line,
Oliveira Hugo,
Thevenot Julie,
Wan Yali,
Brisson Alain R.,
Sandre Olivier,
Miraux Sylvain,
Thiaudiere Eric,
Lecommandoux Sébastien
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201300061
Subject(s) - polymersome , in vivo , bone metastasis , magnetic resonance imaging , cancer research , antibody , cancer , molecular imaging , metastasis , medicine , biomedical engineering , materials science , pathology , immunology , radiology , biology , microbiology and biotechnology , composite material , copolymer , amphiphile , polymer
Multifunctional polymersomes loaded with maghemite nanoparticles and grafted with an antibody, directed against human endothelial receptor 2, are developed as novel MRI contrast agents for bone metastasis imaging. Upon administration in mice bearing bone tumor grown from human breast cancer cells, MR images show targeting and enhanced retention of antibody‐labeled polymersomes at the tumor site.