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Mitigated Cytotoxicity and Tremendously Enhanced Gene Transfection Efficiency of PEI through Facile One‐Step Carbamate Modification
Author(s) -
Yang Chuan,
Cheng Wei,
Teo Pei Yun,
Engler Amanda C.,
Coady Daniel J.,
Hedrick James L.,
Yang Yi Yan
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201300046
Subject(s) - cytotoxicity , transfection , carbamate , surface modification , combinatorial chemistry , chemistry , materials science , nanotechnology , gene , in vitro , organic chemistry , biochemistry
Extremely efficacious gene transfection vector: The rapid and facile modification of PEI with commercially available TMC produces an extremely efficacious gene delivery vector with minimal cytotoxicity. Functionalization of PEI is easily controlled by PEI:cyclic carbonate feed ratios and allows for the addition of functionality. Modified PEIs hold great potential as gene delivery systems due to easy synthesis, scalability, low cost, low toxicity, and outstanding transfection capacity