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Nano‐Graphene Oxide: A Potential Multifunctional Platform for Cancer Therapy
Author(s) -
Gonçalves Gil,
Vila Mercedes,
Portolés MaríaTeresa,
ValletRegi María,
Gracio José,
Marques Paula Alexandrina A. P.
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201300023
Subject(s) - graphene , nano , nanotechnology , materials science , covalent bond , molecule , oxide , surface modification , cancer therapy , carbon fibers , chemistry , composite number , cancer , organic chemistry , composite material , medicine , metallurgy
Nano‐GO is a graphene derivative with a 2D atomic layer of sp 2 bonded carbon atoms in hexagonal conformation together with sp 3 domains with carbon atoms linked to oxygen functional groups. The supremacy of nano‐GO resides essentially in its own intrinsic chemical and physical structure, which confers an extraordinary chemical versatility, high aspect ratio and unusual physical properties. The chemical versatility of nano‐GO arises from the oxygen functional groups on the carbon structure that make possible its relatively easy functionalization, under mild conditions, with organic molecules or biological structures in covalent or non‐covalent linkage. The synergistic effects resulting from the assembly of well‐defined structures at nano‐GO surface, in addition to its intrinsic optical, mechanical and electronic properties, allow the development of new multifunctional hybrid materials with a high potential in multimodal cancer therapy. Herein, a comprehensive review of the fundamental properties of nano‐GO requirements for cancer therapy and the first developments of nano‐GO as a platform for this purpose is presented.