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Neural Tissue Engineering: Hybrid Conducting Polymer–Hydrogel Conduits for Axonal Growth and Neural Tissue Engineering (Adv. Healthcare Mater. 6/2012)
Author(s) -
Abidian Mohammad R.,
Daneshvar Eugene D.,
Egeland Brent M.,
Kipke Daryl R.,
Cederna Paul S.,
Urbanchek Melanie G.
Publication year - 2012
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201290030
Subject(s) - pedot:pss , materials science , self healing hydrogels , neural tissue engineering , nerve guidance conduit , tissue engineering , agarose , conductive polymer , neural engineering , biomedical engineering , electrical conduit , regeneration (biology) , nanotechnology , polymer , layer (electronics) , peripheral nerve , composite material , anatomy , polymer chemistry , neuroscience , computer science , chemistry , medicine , chromatography , biology , microbiology and biotechnology , telecommunications
Conduit hydrogels have been considered for axonal regeneration in both central and peripheral nervous systems. However, a drawback of hydrogel conduits is their lack of mechanical integrity and strength under physiological conditions. On page 762 , M. R. Abidian and co‐workers report a novel method for preparation of mechanically reinforced agarose nerve conduits that are then made conductive by use of a thin layer of conducting polymer pol(3,4‐ethylenedioxythiophene) (PEDOT). The front cover illustrates axon guidance and growth inside a partially coated PEDOT agarose hydrogel conduit.