Premium
Drug Delivery: Surface‐Adhered Composite Poly(Vinyl Alcohol) Physical Hydrogels: Polymersome‐Aided Delivery of Therapeutic Small Molecules (Adv. Healthcare Mater. 6/2012)
Author(s) -
HostaRigau Leticia,
Jensen Bettina E. B.,
Fjeldsø Kit S.,
Postma Almar,
Li Guoxin,
Goldie Kenneth N.,
Albericio Fernando,
Zelikin Alexander N.,
Städler Brigitte
Publication year - 2012
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201290029
Subject(s) - vinyl alcohol , drug delivery , polymersome , materials science , self healing hydrogels , acrylate , morpholine , polymer chemistry , surface modification , copolymer , polymer , nanotechnology , chemical engineering , amphiphile , chemistry , organic chemistry , composite material , engineering
The assembly of a composite hydrogel for substrate‐mediated drug delivery is reported by B. Städler and co‐workers on page 791 . Poly( N ‐acryloyl morpholine)‐ block ‐poly(cholesteryl acrylate)‐ block ‐poly( N ‐acryloyl morpholine) is synthesized and its self‐assembly into polymersomes is shown. Polymersomeaided trapping of a cytotoxic hydrophobic compound in a poly(dopamine)‐coated poly(vinyl alcohol) hydrogel matrix leads to reduction in viability of adhering cells.