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Peptide‐Based Biomaterials: Rational Molecular Design of Complementary Self‐Assembling Peptide Hydrogels (Adv. Healthcare Mater. 5/2012)
Author(s) -
Kyle Stuart,
Felton Susan H,
McPherson Michael J.,
Aggeli Amalia,
Ingham Eileen
Publication year - 2012
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201290024
Subject(s) - self healing hydrogels , peptide , rational design , self assembling peptide , materials science , nanotechnology , fibril , chemistry , biochemistry , polymer chemistry
Rational molecular design of self‐assembling peptide‐based biomaterials is of growing interest for use in numerous healthcare applications. On page 640 A. Aggeli, E. Ingham, and co‐workers report on a binary peptide system P 11 ‐13 and P 11 ‐14, which although monomeric under physiological conditions, upon mixing instantaneously associate to form a selfsupporting hydrogel. Histological analysis through haemotoxylin and eosin staining of the P 11 ‐13/P 11 ‐14 hydrogel reveal an ordered array of large fiber‐like networks with smaller interconnecting fibrils.