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Virus‐Shell Engineering: Biomineralization‐Based Virus Shell‐Engineering: Towards Neutralization Escape and Tropism Expansion (Adv. Healthcare Mater. 4/2012)
Author(s) -
Wang Xiaoyu,
Deng Yongqiang,
Li Shihua,
Wang Guangchuan,
Qin Ede,
Xu Xurong,
Tang Ruikang,
Qin Chengfeng
Publication year - 2012
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201290019
Subject(s) - biomineralization , tissue engineering , neutralization , virus , shell (structure) , biocompatible material , virology , materials science , nanotechnology , chemical engineering , biomedical engineering , medicine , engineering , composite material
Viruses in nanoscale are ideal templates for functional modification by chemical or material methods. On page 443 , Chengfeng Qin, Ruikang Tang, Xiaoyu Wang, and co‐workers present a novel surface modification strategy to afford a biocompatible and bio‐degradable calcium phosphate (CaPi) shell onto single virus. Biomineralization‐based virus shell engineering generates a Trojan virus that can enter cells in a receptor‐independent manner and escape neutralization by antibodies, opening up multiple applications in biomedicines and materials.