Nanoceria‐Triggered Synergetic Drug Release Based on CeO 2 ‐Capped Mesoporous Silica Host–Guest Interactions and Switchable Enzymatic Activity and Cellular Effects of CeO 2 | Zendy

Xu Can | Zendy; Lin Youhui | Zendy; Wang Jiasi | Zendy; Wu Li | Zendy; Wei Weili | Zendy; Ren Jinsong | Zendy; Qu Xiaogang | Zendy

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Nanoceria‐Triggered Synergetic Drug Release Based on CeO 2 ‐Capped Mesoporous Silica Host–Guest Interactions and Switchable Enzymatic Activity and Cellular Effects of CeO 2

Author(s) -

Xu Can,

Lin Youhui,

Wang Jiasi,

Wu Li,

Wei Weili,

Ren Jinsong,

Qu Xiaogang

Publication year - 2013

Publication title -

advanced healthcare materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.288

H-Index - 90

eISSN - 2192-2659

pISSN - 2192-2640

DOI - 10.1002/adhm.201200464

Subject(s) - mesoporous silica , nanoparticle , internalization , a549 cell , mesoporous material , intracellular , drug delivery , biophysics , cancer cell , chemistry , materials science , nanotechnology , chemical engineering , organic chemistry , cell , biochemistry , catalysis , cancer , medicine , biology , engineering

Herein, a pH stimuli‐responsive vehicle for intracellular drug delivery using CeO 2 capped mesoporous silica nanoparticles (MSN) is reported. β‐Cyclodextrin‐modified CeO 2 nanoparticles could cap onto ferrocene‐functionalized mesoporous silica through host–guest interactions. After internalization into A549 cells by a lysosomal pathway, the ferrocenyl moieties are oxidized to ferrocenium ions by CeO 2 lids, which could trigger the uncapping of the CeO 2 and cause the drugs release. Because of the pH‐dependent toxicity, the CeO 2 here behaves as a multi‐purpose entity that not only acts as a lid but also exhibits a synergistic antitumor effect on cancer cells. Meanwhile, the cell protective effect of CeO 2 nanoparticles alone is demonstrated, which ensures that the dissolved CeO 2 nanoparticles can be non‐toxic to normal cells.

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