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A Neutral Envelope‐Type Nanoparticle Containing pH‐Responsive and SS‐Cleavable Lipid‐Like Material as a Carrier for Plasmid DNA
Author(s) -
Akita Hidetaka,
Ishiba Ryohei,
Hatakeyama Hiroto,
Tanaka Hiroki,
Sato Yusuke,
Tange Kota,
Arai Masaya,
Kubo Kazuhiro,
Harashima Hideyoshi
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201200431
Subject(s) - lysosome , nanoparticle , endosome , intracellular , cytosol , dna , nanotechnology , computer science , chemistry , materials science , biophysics , biochemistry , biology , enzyme
SS‐cleavable proton‐activated lipid‐like material (ssPalm) functions as a key element in a lipid nanoparticle in which pDNA is encapsulated. The ssPalm contains dual sensing motifs that can respond to the intracellular environment; a proton‐sponge unit (tertiary amines) that functions in response to an acidic environment (endosome/lysosome), and disulfide bonding that can be cleaved in a reducing environment (cytosol).