A Neutral Envelope‐Type Nanoparticle Containing pH‐Responsive and SS‐Cleavable Lipid‐Like Material as a Carrier for Plasmid DNA | Zendy

Akita Hidetaka | Zendy; Ishiba Ryohei | Zendy; Hatakeyama Hiroto | Zendy; Tanaka Hiroki | Zendy; Sato Yusuke | Zendy; Tange Kota | Zendy; Arai Masaya | Zendy; Kubo Kazuhiro | Zendy; Harashima Hideyoshi | Zendy

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A Neutral Envelope‐Type Nanoparticle Containing pH‐Responsive and SS‐Cleavable Lipid‐Like Material as a Carrier for Plasmid DNA

Author(s) -

Akita Hidetaka,

Ishiba Ryohei,

Hatakeyama Hiroto,

Tanaka Hiroki,

Sato Yusuke,

Tange Kota,

Arai Masaya,

Kubo Kazuhiro,

Harashima Hideyoshi

Publication year - 2013

Publication title -

advanced healthcare materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.288

H-Index - 90

eISSN - 2192-2659

pISSN - 2192-2640

DOI - 10.1002/adhm.201200431

Subject(s) - lysosome , nanoparticle , endosome , intracellular , cytosol , dna , nanotechnology , computer science , chemistry , materials science , biophysics , biochemistry , biology , enzyme

SS‐cleavable proton‐activated lipid‐like material (ssPalm) functions as a key element in a lipid nanoparticle in which pDNA is encapsulated. The ssPalm contains dual sensing motifs that can respond to the intracellular environment; a proton‐sponge unit (tertiary amines) that functions in response to an acidic environment (endosome/lysosome), and disulfide bonding that can be cleaved in a reducing environment (cytosol).

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