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Manipulating Magnetic 3D Spheroids in Hanging Drops for Applications in Tissue Engineering and Drug Screening
Author(s) -
Ho Vincent H. B.,
Guo Wei Mei,
Huang Charlotte L.,
Ho Shu Fen,
Chaw Su Yin,
Tan Ern Yu,
Ng Kee Woei,
Loo Joachim S.C.
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201200408
Subject(s) - spheroid , computer science , drug delivery , tissue engineering , biomedical engineering , nanotechnology , materials science , biology , cell culture , medicine , genetics
Magnetic spheroid manipulation can be carried out in hanging drops to generate distinctly structured heterotypic microtissues through sequential addition of cells or spheroid to homotypic spheroids. These spheroids can also be incorporated in a droplet‐based assay to screen for therapeutic efficacy in prolonged studies. This simple and versatile technique can offer potential benefits in tissue engineering and drug screening applications.