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Cu 2– x Se Nanocrystals with Localized Surface Plasmon Resonance as Sensitive Contrast Agents for In Vivo Photoacoustic Imaging: Demonstration of Sentinel Lymph Node Mapping
Author(s) -
Liu Xin,
Law WingCheung,
Jeon Mansik,
Wang Xianliang,
Liu Maixian,
Kim Chulhong,
Prasad Paras N.,
Swihart Mark T.
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201200388
Subject(s) - photoacoustic imaging in biomedicine , contrast (vision) , nanomaterials , materials science , surface plasmon resonance , nanotechnology , nanocrystal , in vivo , absorption (acoustics) , sentinel lymph node , nanoparticle , computer science , optics , medicine , cancer , physics , artificial intelligence , microbiology and biotechnology , breast cancer , composite material , biology
The promise of a new nanomaterial, Cu 2–x Se nanocrystals, as a contrast agent for photoacoustic imaging is demonstrated . The Cu 2– x Se nanocrystals exhibit strong optical absorption at near infrared wavelengths that can efficiently penetrate tissue. In vivo photoacoustic tomography using this nanomaterial as the contrast agent provides clear three‐dimensional resolution of a sentinel lymph node in a rat model.