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Rapid, Guanosine 5'‐Diphosphate‐Induced, Gelation of Chitosan Sponges as Novel Injectable Scaffolds for Soft Tissue Engineering and Drug Delivery Applications
Author(s) -
Mekhail Mina,
Daoud Jamal,
Almazan Guillermina,
Tabrizian Maryam
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201200371
Subject(s) - drug delivery , chitosan , tissue engineering , guanosine , nanotechnology , materials science , chemistry , computer science , biomedical engineering , biochemistry , engineering
Novel injectable chitosan sponges based on rapid ionic crosslinking using guanosine 5′‐diphosphate are introduced. The rapid gelation, high water retention, desirable physicochemical properties, soft tissue‐like mechanical properties, and excellent cytocompatibility make these injectable sponges promising candidates for tissue regeneration and drug delivery applications.