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Slicing, Stacking and Rolling: Fabrication of Nanostructured Collagen Constructs from Tendon Sections
Author(s) -
Alberti Kyle A.,
Xu Qiaobing
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201200319
Subject(s) - fabrication , slicing , stacking , materials science , microtome , nanotechnology , tendon , computer science , hexagonal crystal system , engineering drawing , crystallography , engineering , computer graphics (images) , chemistry , anatomy , physics , optics , medicine , alternative medicine , organic chemistry , pathology
A novel method for fabricating both multilayer stacked 2D and 3D tubular constructs composed of sheets of aligned collagen fibers is described. These structures are created by decellularizing native tendon and sectioning the material into thin sheets using a cryo‐microtome. This fabrication method preserves the collagens natural strength as well as the fiber structure which would aid in directing aligned cell growth.