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One‐Step Photo Synthesis of Protein–Drug Nanoassemblies for Drug Delivery
Author(s) -
Xie Jinbing,
Cao Yi,
Xia Mao,
Gao Xiang,
Qin Meng,
Wei Jiwu,
Wang Wei
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201200285
Subject(s) - drug delivery , disulfide bond , nanotechnology , drug , nanoparticle , in vivo , anticancer drug , chemistry , computer science , combinatorial chemistry , materials science , biochemistry , pharmacology , medicine , biology , microbiology and biotechnology
Upon controlled UV illumination, disulfide bonds in bovine α‐lactalbumin (BLA) are selectively broken, leading to self‐assembly of the BLA and doxorubicin (DOX) molecules into nanoparticles via hydrophobic interactions and intermolecular disulfide bonds. Such protein–drug nanoparticles have synergistic anticancer activity in vitro and tumor‐homing specificity in vivo, which are of great potential for systemic drug delivery in cancer therapy.