Premium
Chitosan Scaffolds with Unidirectional Microtubular Pores for Large Skeletal Myotube Generation
Author(s) -
Jana Soumen,
Cooper Ashleigh,
Zhang Miqin
Publication year - 2013
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201200177
Subject(s) - myogenesis , chitosan , fabrication , tissue engineering , materials science , anisotropy , nanotechnology , biomedical engineering , skeletal muscle , chemical engineering , anatomy , engineering , physics , biology , optics , medicine , alternative medicine , pathology
3D, uniaxially aligned, microtubular, porous chitosan scaffolds prepared via directional freeze‐drying support the formation of large anisotropic myotubes. Myotubes of ∼550 μm long and ∼50 μm diameter are grown in the scaffolds after two weeks of culture. Porous chitosan scaffolds of varying pore architectures and mechanical properties can be readily produced using this fabrication process for engineering various anisotropic tissues.