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Metabolomics Studies Show Dose‐Dependent Toxicity Induced by SiO 2 Nanoparticles in MRC‐5 Human Fetal Lung Fibroblasts
Author(s) -
Huang ShaoMin,
Zuo Xinbing,
Li Jasmine Jia'En,
Li Sam Fong Yau,
Bay Boon Huat,
Ong Choon Nam
Publication year - 2012
Publication title -
advanced healthcare materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.288
H-Index - 90
eISSN - 2192-2659
pISSN - 2192-2640
DOI - 10.1002/adhm.201200114
Subject(s) - metabolomics , nanotoxicology , toxicity , nanoparticle , viability assay , computational biology , chemistry , nanotechnology , biology , cell , bioinformatics , biochemistry , materials science , organic chemistry
Metabolomics measures a comprehensive range of metabolites and is applied here to understand cellular toxicity of nano‐SiO 2 . Silica nanoparticles are assessed for their effects on MRC‐5 lung fibroblasts and initial investigations reveal no significant alterations in cell viability and morphology. Further metabolomic analysis reveals dose‐dependent alterations in cellular metabolism due to nano‐SiO 2 exposure. This methodology may be a potentially useful analytical platform to investigate nanotoxicity.